Vezf1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within angiogenesis and endothelial cell development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vezf1 |
| Official Name | vascular endothelial zinc finger 1 [Source:RGD Symbol;Acc:1308058] |
| Ensembl ID | ENSRNOG00000009819 |
| Bio databases IDs | |
| Aliases | vascular endothelial zinc finger 1 |
| Synonyms | AL593853.1, CMD1OO, DB1, vascular endothelial zinc finger 1, ZNF161 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vezf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- proliferation
- apoptosis
- G2/M phase
- migration
- development
- network formation by
- differentiation
- abnormal morphology
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vezf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- endothelial cell development
- angiogenesis
- positive regulation of endothelial cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity