Usp15 Gene Summary [Rat]
Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Located in cytoplasm and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp15 |
| Official Name | ubiquitin specific peptidase 15 [Source:RGD Symbol;Acc:628795] |
| Ensembl ID | ENSRNOG00000023202 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 15 |
| Synonyms | 4921514G19Rik, E430033I05Rik, Gcap18, ubiquitin specific peptidase 15, Ubp109, UNPH-2, UNPH4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- cysteine endopeptidase
- transforming growth factor-beta receptor binding
- peptidase
- protein binding activity, bridging
- ubiquitin-specific protease
- DUSP domain
- protein binding
- ubiquitin-like domain
- identical protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- rheumatoid arthritis
- breast cancer
- peripheral arterial disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- Pyoderma gangrenosum
- chronic epilepsy
role in cell
- expression in
- migration
- accumulation in
- differentiation
- formation in
- formation
- invasion by
- lenalidomide sensitivity
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- monoubiquitinated protein deubiquitination
- BMP signaling pathway
- proteolysis
- transforming growth factor beta receptor signaling pathway
- positive regulation of RIG-I signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- identical protein binding
- protein binding
- SMAD binding
- transforming growth factor beta receptor binding
- cysteine-type endopeptidase activity