Gh1 Gene Summary [Rat]
Enables hormone activity. Involved in several processes, including cellular response to alkaline pH; cellular response to thyroid hormone stimulus; and positive regulation of steroid hormone biosynthetic process. Located in collagen-containing extracellular matrix; extracellular space; and secretory granule. Used to study type 1 diabetes mellitus. Biomarker of congenital hypothyroidism; osteoporosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including CSH1 (chorionic somatomammotropin hormone 1) and CSH2 (chorionic somatomammotropin hormone 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gh1 |
| Official Name | growth hormone 1 [Source:RGD Symbol;Acc:2686] |
| Ensembl ID | ENSRNOG00000011207 |
| Bio databases IDs | |
| Aliases | growth hormone 1 |
| Synonyms | DRG-0327, EINECS 235-735-8, GH, Ghb1, GHB5, GH-N, Growth hormone, growth hormone 1, hGH-N, IGHD1A, IGHD1B, IGHD2, Pgh, RNGHGP, somatogen, SOMATROPIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding domain
- prolactin receptor binding
- Growth hormone site i
- Somatotropin/prolactin hormone family
- hormone
- protein binding
- growth hormone receptor binding
- cytokine
- growth hormone site ii
- growth factor
Pathways
Biological processes and signaling networks where the Gh1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- liver disease
- obesity
- heart failure
- hypoglycemia
- end stage renal disease
- chronic renal failure
- impaired glucose tolerance
- fibrosis
- liver cirrhosis
role in cell
- production in
- activation in
- binding in
- expression in
- adhesion
- accumulation
- phosphorylation in
- migration
- quantity
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microsomal fraction
- Cytoplasm
- cell surface
- perinuclear region
- outer membranes
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- trans Golgi network
- perinuclear vesicles
- secretory granules
- extracellular matrix
- membrane processes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- growth hormone receptor signaling pathway
- positive regulation of MAP kinase activity
- positive regulation of growth
- positive regulation of receptor internalization
- organ development
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of multicellular organism growth
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of JAK-STAT cascade
- JAK-STAT cascade
- positive regulation of glucose transport
- cytokine-mediated signaling pathway
- response to estradiol stimulus
- positive regulation of activation of Janus kinase activity
- bone maturation
- response to nutrient levels
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- growth hormone receptor complex
- extracellular space
- endosome lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- metal ion binding
- growth hormone receptor binding
- cytokine activity
- hormone activity
- prolactin receptor binding