VEZF1 Gene Summary [Human]
Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | VEZF1 |
| Official Name | vascular endothelial zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:12949] |
| Ensembl ID | ENSG00000136451 |
| Bio databases IDs | |
| Aliases | vascular endothelial zinc finger 1 |
| Synonyms | AL593853.1, CMD1OO, DB1, vascular endothelial zinc finger 1, ZNF161 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VEZF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- squamous cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- proliferation
- apoptosis
- G2/M phase
- migration
- development
- network formation by
- differentiation
- abnormal morphology
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VEZF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- endothelial cell development
- angiogenesis
- positive regulation of endothelial cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity