Bche Gene Summary [Rat]
Enables choline binding activity and cholinesterase activity. Involved in several processes, including negative regulation of synaptic transmission; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum lumen and extracellular space. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); epilepsy; and inherited metabolic disorder (multiple). Orthologous to human BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bche |
| Official Name | butyrylcholinesterase [Source:RGD Symbol;Acc:619996] |
| Ensembl ID | ENSRNOG00000009826 |
| Bio databases IDs | |
| Aliases | butyrylcholinesterase |
| Synonyms | BCHED, BuChE, Butyrylcholine esterase, BUTYRYLCHOLINESTERASE, C730038G20Rik, CHE1, CHE2, E1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bche often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholinesterase
- Carboxylesterase family
- tryptophan amphiphilic tetramerization domain
- acetylcholinesterase
- binding protein
- alpha/beta hydrolases
- enzyme
- Acetylcholinesterase tetramerization domain
- protein binding
- identical protein binding
- ester bond hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- weight gain
- epithelial cancer
- colorectal cancer
- cognitive impairment
- multiple sclerosis
- depressive disorder
- Alzheimer disease
- Parkinson disease
- traumatic brain injury
role in cell
- proliferation
- differentiation
- cell death
- fibrillogenesis
- response
- development
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- perinuclear space
- neuromuscular junctions
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bche gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetylcholine catabolic process
- negative regulation of cell proliferation
- negative regulation of synaptic transmission
- response to alkaloid
- learning
- cocaine metabolic process
- response to glucocorticoid stimulus
- response to folic acid
- xenobiotic metabolic process
- choline metabolic process
- peptide hormone processing
- neuroblast differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- blood microparticle
- extracellular region
- nuclear envelope lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- identical protein binding
- protein binding
- choline binding
- catalytic activity
- acetylcholinesterase activity
- beta-amyloid binding
- cholinesterase activity
- enzyme binding