Clps Gene Summary [Rat]
Enables enzyme activator activity. Involved in positive regulation of catalytic activity; post-embryonic development; and response to food. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CLPS (colipase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clps |
| Official Name | colipase [Source:RGD Symbol;Acc:2363] |
| Ensembl ID | ENSRNOG00000000510 |
| Bio databases IDs | |
| Aliases | colipase |
| Synonyms | 2200003J09Rik, COL, Colipase, colipase, pancreatic, COLQ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase, C-terminal domain
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- Colipase, N-terminal domain
- COLIPASE
- enzyme activator activity
- proline-rich attachment domain
Pathways
Biological processes and signaling networks where the Clps gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- steatorrhea
- spondylolisthesis
- weight gain
- hyperphagia
role in cell
- growth
- hydrolysis in
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- response to bacterium
- lipid metabolic process
- lipid catabolic process
- digestion
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- lipase binding
- enzyme activator activity