Clec4a Gene Summary [Rat]
Predicted to enable D-mannose binding activity; calcium ion binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including positive regulation of immune response; regulation of cytokine production; and response to fungus. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec4a |
| Official Name | C-type lectin domain family 4, member A [Source:RGD Symbol;Acc:1359662] |
| Ensembl ID | ENSRNOG00000010045 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4, member A |
| Synonyms | Clec4a, Clecsf6, C-type lectin domain family 4, member A, C-type lectin domain family 4, member a2, DCIR, Dcir1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clec4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- calcium ion binding
- Lectin C-type domain
- carbohydrate binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- rheumatoid arthritis
- enthesitis
- arthritis
- ankylosis
- insulin-dependent diabetes mellitus
role in cell
- proliferation
- expression in
- production in
- activation
- number
- accumulation
- downregulation in
- upregulation in
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane