Clec4a2 Gene Summary [Mouse]

Predicted to enable D-mannose binding activity; calcium ion binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Clec4a2
Official Name
C-type lectin domain family 4, member a2 [Source:MGI Symbol;Acc:MGI:1349412]
Ensembl ID
ENSMUSG00000030148
Bio databases IDs NCBI: 26888 Ensembl: ENSMUSG00000030148
Aliases C-type lectin domain family 4, member a2
Synonyms Clec4a, Clecsf6, C-type lectin domain family 4, member A, C-type lectin domain family 4, member a2, DCIR, Dcir1
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec4a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • signaling receptor activity
  • C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  • calcium ion binding
  • Lectin C-type domain
  • carbohydrate binding
  • mannose binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • rheumatoid arthritis
  • enthesitis
  • arthritis
  • ankylosis
  • insulin-dependent diabetes mellitus
regulated by
regulates
role in cell
  • proliferation
  • expression in
  • production in
  • activation
  • number
  • accumulation
  • downregulation in
  • upregulation in
  • degranulation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene-Specific Assays for Results You Can Trust

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