Spag1 Gene Summary [Rat]
Predicted to enable GTP binding activity and hydrolase activity. Predicted to be involved in axonemal dynein complex assembly. Predicted to be located in cilium; cytoplasm; and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 28. Orthologous to human SPAG1 (sperm associated antigen 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spag1 |
| Official Name | sperm associated antigen 1 [Source:RGD Symbol;Acc:1310702] |
| Ensembl ID | ENSRNOG00000010078 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 1 |
| Synonyms | CILD28, CT140, DNAAF13, HEL-S-268, HSD-3.8, SP75, sperm associated antigen 1, TPIS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spag1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Tetratricopeptide repeats
- mitochondrial import receptor subunit TOM70
- tetratricopeptide repeat
- Potential Monad-binding region of RPAP3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- cyclic AMP
- adenosine triphosphate
- TUBG1
- MAPK
- AMPK
- actin
disease
- chronic obstructive pulmonary disease
- primary ciliary dyskinesia type 28
- complex regional pain syndrome
- nocturnal frontal lobe epilepsy type 5
- primary ciliary dyskinesia
- primary ciliary dyskinesia type 28 without situs inversus
- atopic dermatitis
- primary ciliary dyskinesia type 28 with situs inversus
role in cell
- expression in
- activation in
- formation
- phosphorylation in
- formation in
- detachment
- assembly
- detachment in
- assembly in
- extrusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cytosol
- nucleoplasm
- meiotic spindles
- perinuclear focus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spag1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonemal dynein complex assembly
- protein stabilization
- single fertilization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- hydrolase activity