Wdr72 Gene Summary [Rat]
Predicted to be involved in protein localization to plasma membrane. Predicted to act upstream of or within several processes, including ameloblast differentiation; enamel mineralization; and protein-containing complex assembly. Predicted to be located in endosome and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A3. Orthologous to human WDR72 (WD repeat domain 72). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr72 |
| Official Name | WD repeat domain 72 [Source:RGD Symbol;Acc:1563550] |
| Ensembl ID | ENSRNOG00000054889 |
| Bio databases IDs | |
| Aliases | WD repeat domain 72 |
| Synonyms | AI2A3, AW558070, D230040E23, RGD1563550, WD repeat domain 72 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr72 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- hypomaturation type amelogenesis imperfecta type IIA3
- chronic kidney disease
- amelogenesis imperfecta
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatocellular carcinoma
- liver cancer
- non-insulin-dependent diabetes mellitus
role in cell
- cell death
- pH
- differentiation
- polymerization
- organization
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr72 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- enamel mineralization
- extracellular matrix disassembly
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm