Ca3 Gene Summary [Rat]
Enables phosphatase activity. Involved in several processes, including liver regeneration; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and negative regulation of reactive oxygen species biosynthetic process. Located in cytosol; nucleus; and sarcomere. Biomarker of lesion of sciatic nerve; metabolic dysfunction and alcohol associated liver disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human CA3 (carbonic anhydrase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ca3 |
| Official Name | carbonic anhydrase 3 [Source:RGD Symbol;Acc:2241] |
| Ensembl ID | ENSRNOG00000010079 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 3 |
| Synonyms | BB219044, CAIII, CAR3, Carbonic anhydrase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ca3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nickel ion binding
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- phosphatase
- alpha_CA
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- acne vulgaris
- breast cancer
- hypertension
- osteoporosis
- chronic renal failure
- bipolar disorder
- atherosclerosis
- cardiovascular disorder
- alkalosis
regulates
- reactive oxygen species
- hydrogen peroxide
- SRC
- focal adhesion kinase
role in cell
- apoptosis
- growth
- proliferation
- invasiveness
- quantity
- acidification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- sarcomere
- lipid droplets
- cytosol
- brush border
- plasma
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ca3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- nickel cation binding
- carbonate dehydratase activity