Ift43 Gene Summary [Rat]
Predicted to be involved in cilium assembly and intraciliary retrograde transport. Predicted to be located in intercellular bridge and microtubule cytoskeleton. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 3; retinitis pigmentosa 81; and short-rib thoracic dysplasia 18 with polydactyly. Orthologous to human IFT43 (intraflagellar transport 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift43 |
| Official Name | intraflagellar transport 43 [Source:RGD Symbol;Acc:1307392] |
| Ensembl ID | ENSRNOG00000010194 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 43 |
| Synonyms | 1700019E19Rik, C14orf179, CED3, intraflagellar transport 43, RGD1307392, RP81, SRTD18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ift43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intraflagellar transport protein 43
- protein binding
Pathways
Biological processes and signaling networks where the Ift43 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary tip
- cilia
- basal bodies
- centrosome
- centriole
- cytoplasmic bridges
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ift43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centriole
- cytoplasm
- centriolar satellite
- cilium
- intraflagellar transport particle A
Molecular Function
What the gene product does at the molecular level
- protein binding