Wdr35 Gene Summary [Rat]
Involved in several processes, including liver regeneration; negative regulation of biosynthetic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in centrosome and ciliary basal body. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr35 |
| Official Name | WD repeat domain 35 [Source:RGD Symbol;Acc:1564116] |
| Ensembl ID | ENSRNOG00000028783 |
| Bio databases IDs | |
| Aliases | WD repeat domain 35 |
| Synonyms | 4930459M12Rik, 4931430C06, CED2, CFAP118, FAP118, IFT121, IFTA1, mKIAA1336, RGD1564116, SRTD7, Wdr35l, WD repeat domain 35 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Pathways
Biological processes and signaling networks where the Wdr35 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- short rib-polydactyly syndrome
- cranioectodermal dysplasia type 2
- short-rib thoracic dysplasia type 7 with polydactyly
- hereditary disorder
- WDR35-related disorder
- short-rib thoracic dysplasia type 7
- cranioectodermal dysplasia
- short-rib thoracic dysplasia 7 without polydactyly
- digenic short-rib thoracic dysplasia 7 and 20 with polydactyly
- polycystic liver disease
regulates
- nitric oxide
role in cell
- loss
- loss in
- activation
- assembly
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary tip
- cilia
- basal bodies
- centrosome
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar transport
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cilium
- intraflagellar transport particle A
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding