Ift122 Gene Summary [Rat]
Predicted to be involved in several processes, including cilium organization; embryonic morphogenesis; and protein localization to organelle. Predicted to act upstream of or within several processes, including embryonic morphogenesis; negative regulation of keratinocyte proliferation; and smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in several cellular components, including ciliary base; nucleus; and photoreceptor connecting cilium. Predicted to be part of intraciliary transport particle A. Predicted to be active in non-motile cilium. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift122 |
| Official Name | intraflagellar transport 122 [Source:RGD Symbol;Acc:1311302] |
| Ensembl ID | ENSRNOG00000010952 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 122 |
| Synonyms | CED, CED1, CFAP80, FAP80, intraflagellar transport 122, sopb, SPG, WDR10, WDR10p, WDR140 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ift122 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Ift122 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cranioectodermal dysplasia type 1
- exencephaly
- polysyndactyly
- asthma
role in cell
- proliferation
- assembly
- number
- lack
- signal transduction in
- abnormal morphology
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary tip
- Cytoplasm
- cilia
- basal bodies
- cytosol
- connecting cilia
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ift122 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic heart tube left/right pattern formation
- cilium morphogenesis
- limb development
- embryonic body morphogenesis
- spinal cord dorsal/ventral patterning
- embryonic heart tube development
- negative regulation of smoothened signaling pathway
- establishment of protein localization to organelle
- camera-type eye morphogenesis
- intraflagellar transport
- neural tube closure
- embryonic forelimb morphogenesis
- intraflagellar anterograde transport
- intraflagellar retrograde transport
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- cytoplasm
- cilium basal body
- membrane
- cilium
- intraflagellar transport particle A
Molecular Function
What the gene product does at the molecular level
- protein binding