Hexa Gene Summary [Rat]
Predicted to enable acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; and protein heterodimerization activity. Predicted to be involved in ganglioside catabolic process; glycoprotein metabolic process; and glycosaminoglycan metabolic process. Predicted to act upstream of or within several processes, including adult walking behavior; nervous system development; and sensory perception of sound. Predicted to be located in azurophil granule and cytosol. Predicted to be part of beta-N-acetylhexosaminidase complex. Predicted to be active in lysosome and membrane. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hexa |
| Official Name | hexosaminidase subunit alpha [Source:RGD Symbol;Acc:2792] |
| Ensembl ID | ENSRNOG00000010252 |
| Bio databases IDs | |
| Aliases | hexosaminidase subunit alpha |
| Synonyms | beta-N-ACETYLHEXOSAMINIDASE, Hex-1, HEXOSAMINIDASE A, hexosaminidase subunit alpha, hexosaminidase subunit α, TSD, β-N-ACETYLHEXOSAMINIDASE, β-n-acetylhexosaminidase α-chain |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hexa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 20, domain 2
- Glycosyl hydrolase family 20, catalytic domain
- acetylglucosaminyltransferase
- GH20_hexosaminidase
- beta-L-N-acetylhexosaminidase
- enzyme
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- weight loss
- infertility condition
- adult GM2 gangliosidosis
- hexosaminidase A deficiency
- Tay-Sachs disease
- chronic GM2 gangliosidosis
- rheumatoid arthritis
- Tay-Sachs disease variant B1
- growth failure
regulates
- lipid
- hyaluronic acid
- chondroitin sulfate E
- ganglioside
- lyso-ganglioside GM2
- gangliotriaosylceramide II3-sulfate
- lactosylceramide II3-sulfate
- GalNAc-ganglioside GD1a
- chondroitin
- glycosaminoglycan
role in cell
- size
- accumulation in
- quantity
- myelination
- organization
- abnormal morphology
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- Extracellular Space
- cellular membrane
- lysosome
- cytosol
- lysosomal compartment
- azurophil granules
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hexa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- lipid storage
- glycosaminoglycan biosynthetic process
- myelination
- cell morphogenesis involved in neuron differentiation
- ganglioside catabolic process
- sensory perception of sound
- carbohydrate metabolic process
- adult walking behavior
- neuromuscular process controlling posture
- maintenance of location in cell
- skeletal system development
- dermatan sulfate catabolic process
- sexual reproduction
- neuromuscular process controlling balance
- hyaluronan catabolic process
- glycosaminoglycan metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- azurophil granule
- membrane
- cytosol
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylglucosaminyltransferase activity
- protein heterodimerization activity
- beta-N-acetylhexosaminidase activity