Fbxo6 Gene Summary [Rat]
Predicted to enable carbohydrate binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum quality control compartment. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo6 |
| Official Name | F-box protein 6 [Source:RGD Symbol;Acc:620418] |
| Ensembl ID | ENSRNOG00000009217 |
| Bio databases IDs | |
| Aliases | F-box protein 6 |
| Synonyms | FBG2, F-box protein 6, FBS2, FBX6, FBX6A, Fbx6b, FBXO6B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin protein ligase activity
- F-box-like
- F-box associated region
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- DNA repair
- DNA damage checkpoint
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- response to unfolded protein
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- endoplasmic reticulum quality control compartment
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- carbohydrate binding