Mark3 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of protein localization to nucleus; and peptidyl-serine autophosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mark3 |
| Official Name | microtubule affinity regulating kinase 3 [Source:RGD Symbol;Acc:619883] |
| Ensembl ID | ENSRNOG00000010330 |
| Bio databases IDs | |
| Aliases | microtubule affinity regulating kinase 3 |
| Synonyms | 1600015G02Rik, A430080F22RIK, C-TAK1, Emk2, ETK-1, KP78, MAP/microtubule affinity regulating kinase 3, microtubule affinity regulating kinase 3, MPK10, PAR1A, VIPB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mark3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Tau-protein kinase
- Protein Kinases, catalytic domain
- AMPKA_C_like
- Kinase associated domain 1
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- major depression
- obesity
- coronary artery disease
- visual impairment and progressive phthisis bulbi
- insomnia
- squamous-cell carcinoma
- squamous cell cancer
- metabolic syndrome X
role in cell
- expression in
- phosphorylation in
- binding in
- formation
- polarity
- formation in
- nuclear export in
- localization in
- invasive motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mark3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- negative regulation of protein localization to nucleus
- positive regulation of protein binding
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- tau protein binding
- protein serine/threonine kinase activity