Cab39 Gene Summary [Rat]
Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Involved in response to activity and response to thyroid hormone. Located in Z disc. Part of protein-containing complex. Biomarker of hyperthyroidism and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cab39 |
| Official Name | calcium binding protein 39 [Source:RGD Symbol;Acc:1306390] |
| Ensembl ID | ENSRNOG00000017297 |
| Bio databases IDs | |
| Aliases | calcium binding protein 39 |
| Synonyms | calcium binding protein 39, Calcium binding protein 39kDa, CGI-66, MO25, MO25alpha, Mo25 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cab39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- Mo25-like
- kinase binding
- protein kinase binding
- calcium ion binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cab39 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- phosphorylation in
- apoptosis
- proliferation
- activation in
- cell cycle progression
- remodeling
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cab39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to thyroid hormone stimulus
- signal transduction
- cellular hypotonic response
- positive regulation of peptidyl-threonine phosphorylation
- response to activity
- peptidyl-serine phosphorylation
- positive regulation of protein serine/threonine kinase activity
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- Z disc
- extracellular vesicular exosome
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase activator activity
- protein binding
- protein kinase activator activity
- kinase binding