Acp5 Gene Summary [Rat]
Enables acid phosphatase activity. Involved in several processes, including bone resorption; cellular response to zinc ion starvation; and response to L-ascorbic acid. Located in extracellular space. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acp5 |
| Official Name | acid phosphatase 5, tartrate resistant [Source:RGD Symbol;Acc:2022] |
| Ensembl ID | ENSRNOG00000046261 |
| Bio databases IDs | |
| Aliases | acid phosphatase 5, tartrate resistant |
| Synonyms | acid phosphatase 5, tartrate resistant, HPAP, Osteoclast-derived tartrate-resistant acid phosphatase 5b, Pap, TRACP, TRACP5a, TRACP-5b, TRAP, TrATPase, TTRRAP, Uteroferrin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- ferric iron binding
- acid phosphatase
- phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- hydrolase
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the Acp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- spondyloenchondrodysplasia
- multiple sclerosis
- spondyloenchondrodysplasia with immune dysregulation
- breast cancer
- osteosarcoma
- osteosarcomagenesis
- plasma cell myeloma
- ovarian cancer
- MOG antibody disease
role in cell
- phosphorylation in
- migration
- growth
- proliferation
- cell viability
- adhesion
- accumulation in
- transactivation in
- growth in
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Extracellular Space
- cellular membrane
- vesicles
- lysosome
- cytosol
- lysosomal compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of inflammatory response
- negative regulation of interleukin-1 beta production
- bone morphogenesis
- superoxide anion generation
- negative regulation of nitric oxide biosynthetic process
- bone resorption
- negative regulation of superoxide anion generation
- negative regulation of macrophage cytokine production
- response to lipopolysaccharide
- nitric oxide biosynthetic process
- negative regulation of interleukin-12 production
- dephosphorylation
- defense response to Gram-positive bacterium
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- ferric iron binding
- ferrous iron binding
- acid phosphatase activity