Nras Gene Summary [Rat]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in myoblast differentiation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nras |
| Official Name | NRAS proto-oncogene, GTPase [Source:RGD Symbol;Acc:3205] |
| Ensembl ID | ENSRNOG00000023079 |
| Bio databases IDs | |
| Aliases | NRAS proto-oncogene, GTPase |
| Synonyms | ALPS4, CMNS, C-N-Ras, c-N-ras p21, DNA Segment, Chr 3, Mjeffers 1, KRAS, NCMS, neuroblastoma ras oncogene, NRAS1, NRAS proto-oncogene, GTPase, NRASR, NS6, RAS, V-ras |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nras often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphate binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- binding protein
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Nras gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- BMP signaling pathway
- Chemokine Signaling
- CNTF Signaling
- CXCR4 Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PDGF Signaling
- PPAR Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- precursor B-cell acute lymphoblastic leukemia
- plasma cell myeloma
- myelodysplastic syndrome
- refractory multiple myeloma
- neoplasia
- chronic myelomonocytic leukemia
- thrombocytopenia
- non-Hodgkin disease
role in cell
- apoptosis
- cell viability
- expression in
- activation in
- phosphorylation in
- proliferation
- migration
- hypertrophy
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- tertiary granule membrane
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- basolateral membrane
- Golgi membrane
- Golgi stacks
- peri-Golgi vesicles
- perinuclear vesicles
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nras gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- myoblast differentiation
- Ras protein signal transduction
- positive regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
- tertiary granule membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding