Commd7 Gene Summary [Rat]
Enables NF-kappaB binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription, DNA-templated; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Commd7 |
| Official Name | COMM domain containing 7 [Source:RGD Symbol;Acc:1307786] |
| Ensembl ID | ENSRNOG00000010538 |
| Bio databases IDs | |
| Aliases | COMM domain containing 7 |
| Synonyms | 2310010I22Rik, AW060956, C20orf92, COMM domain containing 7, dJ1085F17.3, mU3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Commd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NF-kappaB binding
- COMM domain
- protein binding
- Commd
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast cancer
- chronic periodontal disease
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Commd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- negative regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding