Ctif Gene Summary [Rat]
Predicted to enable translation activator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of translational initiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctif |
| Official Name | cap binding complex dependent translation initiation factor [Source:RGD Symbol;Acc:1311887] |
| Ensembl ID | ENSRNOG00000018342 |
| Bio databases IDs | |
| Aliases | cap binding complex dependent translation initiation factor |
| Synonyms | cap binding complex dependent translation initiation factor, CBP80/20-dependent translation initiation factor, Gm672, KIAA0427, LOC679129 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctif often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIF4G domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctif gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation activator activity