Pithd1 Gene Summary [Rat]
Predicted to be involved in positive regulation of DNA-templated transcription and positive regulation of megakaryocyte differentiation. Predicted to act upstream of or within several processes, including penetration of cumulus oophorus; penetration of zona pellucida; and regulation of proteasomal protein catabolic process. Predicted to be located in sperm cytoplasmic droplet. Predicted to be active in nucleus. Orthologous to human PITHD1 (PITH domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pithd1 |
| Official Name | PITH domain containing 1 [Source:RGD Symbol;Acc:1308048] |
| Ensembl ID | ENSRNOG00000010873 |
| Bio databases IDs | |
| Aliases | PITH domain containing 1 |
| Synonyms | 1110049F12Rik, C1orf128, HT014, PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1, PITH domain containing 1, RGD1308048, Trp26, TXNL1CL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pithd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PITH domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- glioma
- glioma formation
- androgenic alopecia
regulated by
- cocaine
- myoblasts
- mir-590
role in cell
- production in
- expression in
- proliferation
- migration
- morphology
- differentiation
- motility
- development
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pithd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- positive regulation of transcription, DNA-dependent
- spermatid development
- penetration of zona pellucida
- positive regulation of megakaryocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm