Prkar1a Gene Summary [Rat]
Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in female meiotic nuclear division; negative regulation of meiotic nuclear division; and regulation of protein kinase activity. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkar1a |
| Official Name | protein kinase cAMP-dependent type I regulatory subunit alpha [Source:RGD Symbol;Acc:3391] |
| Ensembl ID | ENSRNOG00000049876 |
| Bio databases IDs | |
| Aliases | protein kinase cAMP-dependent type I regulatory subunit alpha |
| Synonyms | 1300018C22Rik, ACRDYS1, ADOHR, cAMP-dependent PK1 R1, Camp-dependent protein kinase type 1, CAR, CNC, CNC1, LOC102724296, PKAR1, PKA R1 alpha, PKA R1 α, PKA RI, Pka rI-α, PKR1, PPNAD1, PRKAR1, Prkar1alpha, protein kinase, cAMP dependent regulatory, type I, alpha, protein kinase, cAMP dependent regulatory, type I, α, protein kinase cAMP-dependent type I regulatory subunit alpha, protein kinase cAMP-dependent type I regulatory subunit α, RI alpha, RIIA, RI α, tissue-specific extinguisher 1, TSE1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkar1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cAMP binding domain
- ubiquitin protein ligase binding
- protein kinase
- dimerization domain
- protein kinase A binding
- protein kinase binding
- protein domain specific binding
- DD_R_PKA_DPY30-like
- protein binding
- cAMP-dependent protein kinase regulator
- Cyclic nucleotide-monophosphate binding domain
- kinase
- Cyclic nucleotide-binding domain
- cAMP-dependent protein kinase inhibitor activity
- 3',5'-cAMP binding
- pseudosubstrate domain
- CAP_ED
Pathways
Biological processes and signaling networks where the Prkar1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Gαs Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Relaxin Signaling
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- tumorigenesis
- adenoma formation
- liver neoplasia
- benign neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
role in cell
- apoptosis
- production in
- expression in
- activation in
- proliferation
- transcription in
- threonine phosphorylation in
- growth
- phosphorylation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- glutaminergic synapse
- cell surface
- perinuclear region
- Nucleus
- Plasma Membrane
- centrosome
- Golgi Apparatus
- Mitochondria
- axonemes
- immunological synapses
- cytosol
- caveolae
- neuromuscular junctions
- synapse
- photoreceptor inner segments
- Z line
- multivesicular bodies
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkar1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cAMP-dependent protein kinase activity
- sarcomere organization
- negative regulation of activated T cell proliferation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cardiac muscle cell proliferation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular response to glucagon stimulus
- regulation of protein phosphorylation
- positive regulation of insulin secretion
- mesoderm formation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- membrane
- cytosol
- neuromuscular junction
- macromolecular complex
- multivesicular body
- axoneme
- cAMP-dependent protein kinase complex
- immunological synapse
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- ubiquitin protein ligase binding
- protein kinase A catalytic subunit binding
- cAMP binding
- cAMP-dependent protein kinase regulator activity
- cAMP-dependent protein kinase inhibitor activity