Crmp1 Gene Summary [Rat]
Predicted to enable several functions, including filamin binding activity; identical protein binding activity; and phosphoprotein binding activity. Involved in neuron development. Predicted to be located in several cellular components, including cytoskeleton; growth cone; and midbody. Predicted to be active in cytosol; postsynapse; and presynapse. Orthologous to human CRMP1 (collapsin response mediator protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crmp1 |
| Official Name | collapsin response mediator protein 1 [Source:RGD Symbol;Acc:2407] |
| Ensembl ID | ENSRNOG00000004781 |
| Bio databases IDs | |
| Aliases | collapsin response mediator protein 1 |
| Synonyms | collapsin response mediator protein 1, DPYSL1, DRP-1, Tuc-1a, ULIP-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crmp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- allantoinase
- cytoskeletal protein binding
- Amidohydrolase family
- phosphoprotein binding
- enzyme
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
- D-hydantoinase
Pathways
Biological processes and signaling networks where the Crmp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- survival
- refractive error
- dysphagia
- cleft palate
- cleft lip
- infection by vesicular stomatitis virus
role in cell
- apoptosis
- activation in
- formation in
- migration
- invasion
- growth
- formation
- quantity
- invasiveness
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- presynaptic regions
- postsynaptic region
- actin cytoskeleton
- Nucleus
- centrosome
- midbody
- cytosol
- growth cone
- neuritic shafts
- cellular protrusions
- mitotic spindle
- perikaryon
- dendrites
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crmp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- negative regulation of neuron projection development
- nervous system development
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- growth cone
- centrosome
- spindle
- cytosol
- midbody
- perikaryon
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- identical protein binding
- protein binding
- dihydropyrimidinase activity
- filamin binding