Mapk11 Gene Summary [Rat]
Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk11 |
| Official Name | mitogen-activated protein kinase 11 [Source:RGD Symbol;Acc:1309340] |
| Ensembl ID | ENSRNOG00000006984 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 11 |
| Synonyms | LOC679007, mitogen-activated protein kinase 11, p38-2, P38B, P38 beta, P38BETA2, p38 beta Mapk, p38 Mapk β, P38 β, p38 β Mapk, PRKM11, SAPK2, SAPK2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mapk11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- calmodulin binding domain
- ATP binding
- threonine-glycine-tyrosine activation motif
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- MAP kinase
Pathways
Biological processes and signaling networks where the Mapk11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- April Mediated Signaling
- ATM Signaling
- B Cell Activating Factor Signaling
- BMP signaling pathway
- CD40 Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Parkinson's Signaling
- PEDF Signaling
- RANK Signaling in Osteoclasts
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Toll-like Receptor Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteosarcoma
- cardiac fibrosis
- metastatic progressive colorectal cancer
- metastatic colorectal cancer
- advanced colon cancer
- metastatic colon cancer
- colorectal cancer
- undifferentiated gastric carcinoma
- metastatic gastrointestinal stromal tumor
- gastric adenocarcinoma
role in cell
- expression in
- apoptosis
- adhesion
- cell death
- proliferation
- activation in
- differentiation
- phosphorylation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mapk11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- p38MAPK cascade
- stress-activated protein kinase signaling cascade
- cellular senescence
- cardiac muscle cell proliferation
- positive regulation of erythrocyte differentiation
- bone development
- cellular response to UV-B
- positive regulation of interleukin-12 production
- positive regulation of gene expression
- osteoblast differentiation
- cellular response to interleukin-1
- intracellular signal transduction
- positive regulation of muscle cell differentiation
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity