Klhl25 Gene Summary [Rat]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl25 |
| Official Name | kelch-like family member 25 [Source:RGD Symbol;Acc:1310815] |
| Ensembl ID | ENSRNOG00000010959 |
| Bio databases IDs | |
| Aliases | kelch-like family member 25 |
| Synonyms | 2810402K13RIK, Enc-1, ENC-2, kelch-like 25, kelch-like family member 25, LOC100129082, RGD1310815 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klhl25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klhl25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- positive regulation of fatty acid oxidation
- regulation of translational initiation
- protein ubiquitination
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- Cul3-RING ubiquitin ligase complex