Klhl25 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of fatty acid oxidation; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in central nervous system; nervous system; peripheral nervous system; and retina. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl25 |
| Official Name | kelch-like 25 [Source:MGI Symbol;Acc:MGI:2668031] |
| Ensembl ID | ENSMUSG00000055652 |
| Bio databases IDs | |
| Aliases | kelch-like 25 |
| Synonyms | 2810402K13RIK, Enc-1, ENC-2, kelch-like 25, kelch-like family member 25, LOC100129082, RGD1310815 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- positive regulation of fatty acid oxidation
- regulation of translational initiation
- protein ubiquitination
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- Cul3-RING ubiquitin ligase complex