Pon2 Gene Summary [Rat]
Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to be located in plasma membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease and obesity. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pon2 |
| Official Name | paraoxonase 2 [Source:RGD Symbol;Acc:1309954] |
| Ensembl ID | ENSRNOG00000009112 |
| Bio databases IDs | |
| Aliases | paraoxonase 2 |
| Synonyms | 6330405I24Rik, A-esterase 2, paraoxonase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pon2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aryldialkylphosphatase
- strictosidine synthase
- protein homodimerization
- enzyme
- protein binding
- arylesterase
- lactonohydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- psoriasis
- susceptibility to coronary artery disease
- Alzheimer disease
role in cell
- expression in
- apoptosis
- chemotaxis
- oxidative stress response
- peroxidation in
- biosynthesis in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- endoplasmic reticulum fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- apical membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pon2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to toxin
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- metal ion binding
- arylesterase activity