Psmc3 Gene Summary [Rat]
Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in modulation by host of viral transcription; positive regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in perinuclear region of cytoplasm. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc3 |
| Official Name | proteasome 26S subunit, ATPase 3 [Source:RGD Symbol;Acc:61905] |
| Ensembl ID | ENSRNOG00000011414 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 3 |
| Synonyms | DCIDP, Proteasome 26S Subunit 3, Proteasome 26s subunit atpase 3, proteasome 26S subunit, ATPase 3, proteasome (prosome, macropain) 26S subunit, ATPase 3, RPT5, S6', S6A, TBP-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psmc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- ATP-binding domain
- isomerase
- leucine zipper domain
- coiled-coil domain
- enzyme
- protein binding
- identical protein binding
- AAA+ lid domain
- helicase domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- ATPase domain
- HbYX motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- non-insulin-dependent diabetes mellitus
- venous thromboembolism
- deafness, cataract, impaired intellectual development, and polyneuropathy
- neuroticism
- depressive disorder
- neurodevelopmental disorder
- hypertension
- hereditary disorder
- infection by HIV-1
role in cell
- expression in
- proliferation
- growth
- transcription in
- colony formation
- assembly in
- cell viability
- stabilization in
- degradation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- perinuclear region
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psmc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transcription from RNA polymerase II promoter
- modulation by host of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- membrane
- cytoplasmic mRNA processing body
- cytosol
- proteasome accessory complex
- proteasome complex
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding