Cpe Gene Summary [Rat]
Enables carboxypeptidase activity; cobalt ion binding activity; and protein domain specific binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; generation of neurons; and peptide hormone processing. Located in several cellular components, including dense core granule; perikaryon; and synaptic membrane. Human ortholog(s) of this gene implicated in alcohol dependence; coronary artery disease; obesity; and type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpe |
| Official Name | carboxypeptidase E [Source:RGD Symbol;Acc:2394] |
| Ensembl ID | ENSRNOG00000043387 |
| Bio databases IDs | |
| Aliases | carboxypeptidase E |
| Synonyms | BDVS, CARBE, carboxypeptidase E, Carboxypeptidase H, CPH, Cph-1, fat, IDDHH, NF-alpha1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxypeptidase
- Zn_pept domain
- cell adhesion molecule binding
- peptidase
- metallocarboxypeptidase
- carboxypeptidase E
- protein domain specific binding
- M14 family of metallocarboxypeptidases and related proteins
- protein binding
- Carboxypeptidase regulatory-like domain
- transition metal ion binding
- Zinc carboxypeptidase
- neurexin binding
- Peptidase_M14NE-CP-C_like
- CarboxypepD_reg-like domain
Pathways
Biological processes and signaling networks where the Cpe gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- obesity
- BDV syndrome
- autosomal dominant polycystic kidney disease
- breast cancer
- hyperglycemia
- hyperphagia
- hereditary disorder
- tremor
- hyperinsulinism
role in cell
- expression in
- proliferation
- migration
- apoptosis
- transcription in
- activation
- transmembrane potential
- response by
- granulogenesis in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- Extracellular Space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- secretory granule membrane
- microsome
- synaptic membrane
- secretory vesicles
- secretory granules
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiac left ventricle morphogenesis
- protein modification process
- neuropeptide signaling pathway
- insulin processing
- peptide hormone secretion
- peptide metabolic process
- protein localization in membrane
- Wnt receptor signaling pathway
- protein localization in secretory granule
- protein processing
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular space
- extracellular vesicular exosome
- transport vesicle membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- zinc ion binding
- protein binding
- metallocarboxypeptidase activity
- neurexin family protein binding
- cell adhesion molecule binding