Dnajc13 Gene Summary [Rat]
Predicted to be involved in endosome organization; receptor-mediated endocytosis; and regulation of intracellular transport. Predicted to be located in cytosol and early endosome membrane. Predicted to be part of WASH complex. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc13 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C13 [Source:RGD Symbol;Acc:1308046] |
| Ensembl ID | ENSRNOG00000011491 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C13 |
| Synonyms | D030002L11Rik, DnaJ heat shock protein family (Hsp40) member C13, FLJ25863, Gm1124, KIAA0678, mKIAA0678, PARK21, RME-8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnajc13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- GYF domain 2
- protein binding
- DNAJ protein RME-8 N-terminal
Pathways
Biological processes and signaling networks where the Dnajc13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- secretory granule membrane
- cytosol
- lysosome membrane
- endosomal membrane
- exosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnajc13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- protein transport
- osteoblast differentiation
- receptor-mediated endocytosis
- regulation of early endosome to late endosome transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- secretory granule membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- endosome membrane
- WASH complex
- azurophil granule membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding