Rab3c Gene Summary [Rat]
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and myosin V binding activity. Predicted to be involved in antigen processing and presentation and exocytosis. Predicted to act upstream of or within regulation of exocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3c |
| Official Name | RAB3C, member RAS oncogene family [Source:RGD Symbol;Acc:620923] |
| Ensembl ID | ENSRNOG00000011623 |
| Bio databases IDs | |
| Aliases | RAB3C, member RAS oncogene family |
| Synonyms | 2700062I01Rik, 3110015B08Rik, 3110037E15Rik, RAB3C, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- myosin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- adenoma formation
- aldosterone producing adrenocortical adenoma
- central nervous system infection
- dyspnea
- cyanosis
- adrenal medullary hyperplasia
regulates
- transferrin receptor
- growth hormone
- neurotransmitter
role in cell
- activation
- exocytosis by
- exocytosis
- transmission
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- insulin secretory granules
- synaptic vesicles
- perinuclear vesicles
- dense-core vesicles
- secretory granules
- clathrin-coated vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen processing and presentation
- regulation of exocytosis
- protein secretion
- exocytosis
Cellular Component
Where in the cell the gene product is active
- endosome
- perinuclear region of cytoplasm
- synaptic vesicle
- vesicle
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GTP-dependent protein binding
- myosin V binding