Rab8b Gene Summary [Rat]
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | Rab8b |
| Official Name | RAB8B, member RAS oncogene family [Source:RGD Symbol;Acc:628764] |
| Ensembl ID | ENSRNOG00000018009 |
| Bio databases IDs | |
| Aliases | RAB8B, member RAS oncogene family |
| Synonyms | 5930437D16, D330025I23RIK, LOC51762, RAB8B, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- protein domain specific binding
- enzyme
- protein binding
- receptor binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab8b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- infection by Dengue virus 2
role in cell
- differentiation
- growth
- formation
- abnormal morphology
- activation
- cross-presentation by
- elimination in
- elimination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- basal compartment
- perinuclear region
- membrane surface
- Plasma Membrane
- Golgi Apparatus
- membrane compartment
- cytosol
- Golgi membrane
- peroxisome membrane
- endosomal membrane
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- cell tip
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab8b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- protein import into peroxisome membrane
- positive regulation of corticotropin secretion
- antigen processing and presentation
- protein secretion
- exocytosis
- endocytic recycling
- positive regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- trans-Golgi network transport vesicle
- phagocytic vesicle
- plasma membrane
- peroxisomal membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- endosome
- cell tip
- phagocytic vesicle membrane
- endosome membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- TPR domain binding
- GTPase activity
- GDP binding
- receptor binding