Tfap2d Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within inferior colliculus development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human TFAP2D (transcription factor AP-2 delta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfap2d |
| Official Name | transcription factor AP-2 delta [Source:RGD Symbol;Acc:1304864] |
| Ensembl ID | ENSRNOG00000011642 |
| Bio databases IDs | |
| Aliases | transcription factor AP-2 delta |
| Synonyms | AP-2delta, AP2-like protein i, Ap2 δ, Tcfap2d, TFAP2BL1, transcription factor AP-2 delta, transcription factor AP-2, delta, transcription factor AP-2 δ, transcription factor AP-2, δ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfap2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Transcription factor AP-2
- transcription activation domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Tfap2d gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfap2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anatomical structure development
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- inferior colliculus development
- regulation of cell proliferation
- negative regulation of neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity