Mt2A Gene Summary [Rat]
Enables cadmium ion binding activity and zinc ion binding activity. Involved in astrocyte activation. Predicted to be located in cytoplasm and nucleus. Biomarker of Alzheimer's disease; kidney failure; median neuropathy; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT2A (metallothionein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mt2A |
| Official Name | metallothionein 2A [Source:RGD Symbol;Acc:1592345] |
| Ensembl ID | ENSRNOG00000043098 |
| Bio databases IDs | |
| Aliases | metallothionein 2A |
| Synonyms | LOC682651, LOC689415, metallothionein 2, metallothionein 2A, MT1B, MT-2, MT-II, MTIIa |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mt2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Metallothionein
- protein binding
- cadmium ion binding
Pathways
Biological processes and signaling networks where the Mt2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- COVID-19
- chronic obstructive pulmonary disease
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- neuropathy
- tubulo-interstitial fibrosis
- Behcet disease
role in cell
- proliferation
- growth
- differentiation
- apoptosis
- cell viability
- molecular cleavage in
- number
- quantity
- cell cycle progression
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mt2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detoxification of copper ion
- negative regulation of growth
- cellular copper ion homeostasis
- cellular response to zinc ion
- cellular response to cadmium ion
- cellular zinc ion homeostasis
- cellular response to interleukin-3
- cellular response to copper ion
- cellular response to erythropoietin
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metal ion binding