Hnrnph2 Gene Summary [Rat]
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual developmental disorder bain type. Orthologous to human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnph2 |
| Official Name | heterogeneous nuclear ribonucleoprotein H2 [Source:RGD Symbol;Acc:1549784] |
| Ensembl ID | ENSRNOG00000011661 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein H2 |
| Synonyms | DXHXS1271E, FLJ58205, FTP3, H', heterogeneous nuclear ribonucleoprotein H2, Heterogeneous nuclear riboprotein h2, HNRNP, hnRNPH', HNRPH', HNRPH2, MRXSB, NRPH2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnrnph2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- RNPHF zinc finger
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Bain type X-linked syndromic mental retardation
- hereditary disorder
- X-linked complex neurodevelopmental disorder
- neurodevelopmental disorder
role in cell
- binding in
- growth
- migration
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
- nucleoplasm
- interchromatin granule clusters
- chromatin
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnrnph2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding