Bcl2l1 Gene Summary [Rat]
Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of transport; and regulation of apoptotic process. Located in bounding membrane of organelle; clathrin-coated pit; and cytosol. Is active in synaptic vesicle. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; hepatocellular carcinoma; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l1 |
| Official Name | Bcl2-like 1 [Source:RGD Symbol;Acc:2200] |
| Ensembl ID | ENSRNOG00000007946 |
| Bio databases IDs | |
| Aliases | Bcl2-like 1 |
| Synonyms | bBclxl, BCL2L, BCL2-like 1, BCLX, Bcl-X beta, Bclx gamma, BCL-XL/S, Bcl-X β, Bclx γ, PPP1R52 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcl2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- apoptosis regulator
- Bcl-2_like
- protein kinase binding
- caspase inhibitor activity
- enzyme binding
- clathrin binding
- PP1 binding domain
- protein domain specific binding
- Bcl-xL binding domain
- protein binding
- identical protein binding
- phosphorylation site
- pocket domain
- Bcl-2 homology region 4
- BH3 binding domain
- binding protein
- C-terminal transmembrane domain
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- membrane attachment signal
- transmembrane domain
- tail domain
- loop domain
Pathways
Biological processes and signaling networks where the Bcl2l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Erythropoietin Signaling
- Glucocorticoid Receptor Signaling
- Huntington's Disease Signaling
- IL-10 Signaling
- IL-4 Signaling
- Induction of Apoptosis by HIV1
- JAK/Stat Signaling
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- p53 Signaling
- Pancreatic Adenocarcinoma Signaling
- PEDF Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Tissue Factor in Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- cancer
- neoplasia
- ovarian cancer
- thrombocytosis
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- cell death
- expression in
- apoptosis
- binding
- replication in
- degradation in
- proliferation
- survival
- accumulation in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- membrane fraction
- mitochondrial fraction
- synaptic vesicle membrane
- presynaptic regions
- cell surface
- cell periphery
- intracellular space
- outer membranes
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- outer leaflet
- perinucleolar rings
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial outer membrane
- nuclear foci
- nuclear envelope
- synaptic vesicles
- photoreceptor inner segments
- clathrin-coated pits
- perikaryon
- axons
- exosomes
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcl2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- apoptotic process in bone marrow
- male gonad development
- response to cycloheximide
- negative regulation of developmental process
- extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of execution phase of apoptosis
- negative regulation of neuron apoptotic process
- positive regulation of mononuclear cell proliferation
- cellular response to amino acid stimulus
- apoptotic mitochondrial changes
- epithelial cell proliferation
- dendritic cell apoptotic process
- in utero embryonic development
- regulation of mitochondrial membrane potential
- regulation of cytokinesis
- defense response to virus
- cellular response to alkaloid
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
- neuron apoptotic process
- germ cell development
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- germ cell programmed cell death
- negative regulation of release of cytochrome c from mitochondria
- spermatogenesis
- fertilization
- DNA damage response, signal transduction resulting in induction of apoptosis
- dendritic cell proliferation
- endocytosis
- regulation of mitochondrial membrane permeability
- regulation of growth
- ovarian follicle development
- hepatocyte apoptotic process
- cellular response to gamma radiation
- negative regulation of dendritic cell apoptotic process
- negative regulation of apoptotic process
- release of cytochrome c from mitochondria
- negative regulation of reproductive process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- centrosome
- mitochondrial matrix
- Bcl-2 family protein complex
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
- synaptic vesicle membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- BH3 domain binding
- protein kinase binding
- identical protein binding
- protein binding