Fto Gene Summary [Rat]
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytosol and nuclear speck. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fto |
| Official Name | FTO, alpha-ketoglutarate dependent dioxygenase [Source:RGD Symbol;Acc:1305121] |
| Ensembl ID | ENSRNOG00000011728 |
| Bio databases IDs | |
| Aliases | FTO, alpha-ketoglutarate dependent dioxygenase |
| Synonyms | ALKBH9, BMIQ14, FTO alpha-ketoglutarate dependent dioxygenase, FTO, alpha-ketoglutarate dependent dioxygenase, FTO α-ketoglutarate dependent dioxygenase, FTO, α-ketoglutarate dependent dioxygenase, GDFD, IFEX9, mKIAA1752, RGD1305121 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fto often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- 2-oxoglutarate:oxygen oxidoreductase
- demethylase activity
- enzyme
- protein binding
- FTO catalytic domain
- FTO C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- major depression
- metabolic syndrome X
- obesity
- diabetes mellitus
- atrial fibrillation
- aortic valve disease
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- knee osteoarthritis
role in cell
- signaling in
- expression in
- apoptosis
- quantity
- autophagy in
- cell viability
- proliferation
- phosphorylation in
- invasion
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fto gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- regulation of white fat cell proliferation
- regulation of brown fat cell differentiation
- mRNA destabilization
- regulation of multicellular organism growth
- snRNA processing
- regulation of respiratory system process
- temperature homeostasis
- RNA repair
- adipose tissue development
- regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ferrous iron binding
- oxidative RNA demethylase activity
- oxidative DNA demethylase activity
- transferase activity