Cbl Gene Summary [Rat]
Enables several functions, including SH3 domain binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; mast cell degranulation; and protein ubiquitination. Located in focal adhesion; growth cone; and perinuclear region of cytoplasm. Used to study transient cerebral ischemia. Biomarker of congenital diaphragmatic hernia; hyperglycemia; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbl |
| Official Name | Cbl proto-oncogene [Source:RGD Symbol;Acc:1561386] |
| Ensembl ID | ENSRNOG00000008444 |
| Bio databases IDs | |
| Aliases | Cbl proto-oncogene |
| Synonyms | 4732447J05Rik, Casitas B-lineage lymphoma, Cbl1, CBL2, CBLA, Cbl proto-oncogene, Cbl ubiquitin ligase, C-CBL, FRA11B, LOC283153, NSLL, p120 Cbl, RGD1561386, RNF55 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cbl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- transcription regulator
- CBL proto-oncogene N-terminal domain 1
- ephrin receptor binding
- leucine zipper domain
- enzyme
- proline rich domain
- docking domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Src homology 2 (SH2) domain
- zinc-RING finger domain
- UBA domain-like superfamily
- proline glycine arginine motif
- protein kinase binding
- tyrosine kinase binding domain
- SH2 like domain
- pro-x-x-x-pro-arg motif
- ubiquitin protein ligase activity
- linker domain
- protein binding
- phosphotyrosine binding domain
- Src-homology 2 binding domain
- acidic domain
- SH3-domain binding
- phosphorylation site
- arginine proline-rich domain
- phosphoinositide 3-kinase binding
- RING-type zinc-finger
- ubiquitin-protein transferase activity
- CBL proto-oncogene N-terminus, EF hand-like domain
- tyrosine phosphorylation site
- four-helix bundle domain
- CBL proto-oncogene N-terminus, SH2-like domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Cbl gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Insulin Receptor Signaling
- Molecular Mechanisms of Cancer
- PI3K Signaling in B Lymphocytes
- Protein Ubiquitination Pathway
- PTEN Signaling
- RANK Signaling in Osteoclasts
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- fibrosis
- weight gain
- myeloproliferative neoplasm
- myeloproliferative disorder
- myelodysplastic syndrome
- Noonan spectrum disorder
- Noonan syndrome-like disorder without juvenile myelomonocytic leukemia
- secondary acute myeloid leukemia
role in cell
- production in
- activation in
- binding in
- expression in
- cell viability
- adhesion
- phosphorylation in
- migration
- cellular infiltration by
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- cilia
- perinuclear Golgi regions
- cell surface
- intracellular space
- perinuclear region
- focal adhesions
- podosomes
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- cytosol
- membrane ruffles
- growth cone
- early endosomes
- late endosomes
- membrane rafts
- cell membrane leading edge
- axons
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cbl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- male gonad development
- positive regulation of epidermal growth factor receptor signaling pathway
- response to starvation
- negative regulation of epidermal growth factor receptor signaling pathway
- mast cell degranulation
- ubiquitin-dependent endocytosis
- response to ethanol
- cytokine-mediated signaling pathway
- regulation of Rap protein signal transduction
- entry of bacterium into host cell
- cellular response to hypoxia
- response to testosterone stimulus
- response to gamma radiation
- positive regulation of receptor-mediated endocytosis
- protein autoubiquitination
- signal transduction
- cellular response to platelet-derived growth factor stimulus
- protein polyubiquitination
- response to DNA damage stimulus
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- negative regulation of apoptotic process
- response to activity
- regulation of platelet-derived growth factor receptor-alpha signaling pathway
- positive regulation of protein kinase B signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- growth cone
- perinuclear region of cytoplasm
- focal adhesion
- membrane raft
- cilium
- cytosol
- Golgi apparatus
- plasma membrane
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- ubiquitin-protein ligase activity
- protein binding
- cadherin binding
- calcium ion binding
- ephrin receptor binding
- SH3 domain binding
- receptor tyrosine kinase binding