Lrrc7 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in positive regulation of neuron projection development and response to toluene. Located in several cellular components, including axon initial segment; dendritic spine; and filopodium. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc7 |
| Official Name | leucine rich repeat containing 7 [Source:RGD Symbol;Acc:708527] |
| Ensembl ID | ENSRNOG00000011980 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 7 |
| Synonyms | AK122498, B230334C09Rik, DENSIN, DENSIN 180, KIAA1365, leucine rich repeat containing 7, LOC117284, mKIAA1365 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrrc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- canonical PDZ domain
- cytosolic tail domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- idiopathic scoliosis
- hearing loss
- major depression
- hyperactive behavior
- coronary artery disease
- orofacial cleft
- attention deficit hyperactivity disorder
role in cell
- development
- morphology
- long term synaptic depression
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- actin cytoskeleton
- centrosome
- cytosol
- synaptic membrane
- nucleoplasm
- dendritic spines
- synapse
- filopodia
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrrc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- establishment or maintenance of epithelial cell apical/basal polarity
- positive regulation of neuron projection development
- receptor clustering
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- initial segment
- adherens junction
- specific granule lumen
- postsynaptic membrane
- cytosol
- extracellular region
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding