Lrrc7 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and protein localization to membrane. Predicted to be located in actin cytoskeleton; dendritic spine; and filopodium. Predicted to be active in several cellular components, including axon initial segment; basolateral plasma membrane; and postsynaptic density membrane. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; cortical plate; esophagus mesenchyme; spinal cord; and trachea mesenchyme. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc7 |
| Official Name | leucine rich repeat containing 7 [Source:MGI Symbol;Acc:MGI:2676665] |
| Ensembl ID | ENSMUSG00000028176 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 7 |
| Synonyms | AK122498, B230334C09Rik, DENSIN, DENSIN 180, KIAA1365, leucine rich repeat containing 7, LOC117284, mKIAA1365 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- canonical PDZ domain
- cytosolic tail domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- idiopathic scoliosis
- hearing loss
- major depression
- hyperactive behavior
- coronary artery disease
- orofacial cleft
- attention deficit hyperactivity disorder
role in cell
- development
- morphology
- long term synaptic depression
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- actin cytoskeleton
- centrosome
- cytosol
- synaptic membrane
- nucleoplasm
- dendritic spines
- synapse
- filopodia
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- establishment or maintenance of epithelial cell apical/basal polarity
- positive regulation of neuron projection development
- receptor clustering
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- initial segment
- adherens junction
- specific granule lumen
- postsynaptic membrane
- cytosol
- extracellular region
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding