Nqo2 Gene Summary [Rat]
Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nqo2 |
| Official Name | N-ribosyldihydronicotinamide:quinone reductase 2 [Source:RGD Symbol;Acc:1303320] |
| Ensembl ID | ENSRNOG00000017820 |
| Bio databases IDs | |
| Aliases | N-ribosyldihydronicotinamide:quinone reductase 2 |
| Synonyms | DHQV, DIA6, LOC285771, NMO2, NMOR2, N-ribosyldihydronicotinamide:quinone dehydrogenase 2, N-ribosyldihydronicotinamide quinone reductase 2, Ox2, QR2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nqo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- electron carrier
- binding protein
- zinc ion binding
- oxidoreductase
- dihydronicotinamide riboside quinone reductase
- protein homodimerization
- enzyme
- protein binding
- nitrogenous compound oxidoreductase
- Flavodoxin-like fold
- NADPH-dependent FMN reductase
Pathways
Biological processes and signaling networks where the Nqo2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin neoplasia
- breast cancer
- liver neoplasia
- cancer
- cleft lip
- thrombocytosis
- neoplasia
- Parkinson disease
- myeloid hyperplasia
- Alzheimer disease
role in cell
- expression in
- quantity
- activation in
- production in
- number
- proliferation
- apoptosis
- homing
- transmembrane potential
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nqo2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- chloride ion binding
- zinc ion binding
- protein binding
- dihydronicotinamide riboside quinone reductase activity
- protein homodimerization activity
- NAD(P)H dehydrogenase (quinone) activity
- oxidoreductase activity
- electron carrier activity
- oxidoreductase activity, acting on other nitrogenous compounds as donors