Slc18a1 Gene Summary [Rat]
Enables enzyme binding activity; monoamine:proton antiporter activity; and serotonin:sodium:chloride symporter activity. Involved in several processes, including cellular response to lithium ion; positive regulation of dopamine secretion; and serotonin uptake. Predicted to be located in endoplasmic reticulum membrane and secretory granule membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc18a1 |
| Official Name | solute carrier family 18 member A1 [Source:RGD Symbol;Acc:3693] |
| Ensembl ID | ENSRNOG00000011992 |
| Bio databases IDs | |
| Aliases | solute carrier family 18 member A1 |
| Synonyms | 4832416I10Rik, CGAT, LOC684870, solute carrier family 18 member A1, solute carrier family 18 (vesicular monoamine), member 1, VAT1, VMAT-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc18a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- monoamine:hydrogen antiporter
- monoamine transporter
- serotonin:sodium symporter
- enzyme binding
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Slc18a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- essential hypertension
- schizophrenia
- obesity
- human immunodeficiency virus I infection
- cardiovascular disorder
- attention deficit hyperactivity disorder
- MYCN amplification negative neuroblastoma
- neuroblastoma formation
- bipolar disorder
regulates
- H+
- 5-hydroxytryptamine
- monoamines
- dopamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- vesicles
- Endoplasmic Reticulum
- secretory granule membrane
- endoplasmic reticulum membrane
- synaptic vesicles
- synapse
- transport vesicles
- dense-core vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc18a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- serotonin uptake
- xenobiotic transport
- monoamine transport
- synaptic vesicle amine transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- clathrin sculpted monoamine transport vesicle membrane
- terminal button
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- monoamine:hydrogen antiporter activity
- monoamine transmembrane transporter activity
- serotonin:sodium symporter activity