Ctsa Gene Summary [Rat]
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of chaperone-mediated autophagy; proteolysis; and regulation of protein stability. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsa |
| Official Name | cathepsin A [Source:RGD Symbol;Acc:1309070] |
| Ensembl ID | ENSRNOG00000015857 |
| Bio databases IDs | |
| Aliases | cathepsin A |
| Synonyms | Cathepsin A, GLB2, GSL, LYSOSOMAL SERINE CARBOXYPEPTIDASE, NGBE, PPCA, PPGB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxypeptidase
- carboxypeptidase C
- PLN02209
- serine-type carboxypeptidase
- peptidase
- Serine carboxypeptidase
- protein binding
- enzyme activator activity
Pathways
Biological processes and signaling networks where the Ctsa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- galactosialidosis
- hereditary disorder
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- peripheral arterial disease
- systemic lupus erythematosus
- idiopathic hydrops fetalis
- galactosialidosis type II
- juvenile/adult type galactosialidosis
role in cell
- apoptosis
- accumulation in
- number
- diameter
- quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- multivesicular domain
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Extracellular Space
- lysosome
- Endoplasmic Reticulum
- lysosomal compartment
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- proteolysis
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- lysosomal lumen
- extracellular region
- azurophil granule lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- serine-type carboxypeptidase activity
- enzyme activator activity