Pex7 Gene Summary [Rat]
Predicted to enable enzyme binding activity; peroxisome matrix targeting signal-2 binding activity; and protein homodimerization activity. Predicted to be involved in ether lipid biosynthetic process and protein import into peroxisome matrix. Predicted to act upstream of or within several processes, including endochondral ossification; fatty acid beta-oxidation; and protein targeting to peroxisome. Predicted to be located in peroxisome. Predicted to be active in cytosol and peroxisomal matrix. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 9B and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex7 |
| Official Name | peroxisomal biogenesis factor 7 [Source:RGD Symbol;Acc:1308483] |
| Ensembl ID | ENSRNOG00000012322 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 7 |
| Synonyms | MmPEX7, PBD9B, peroxisomal biogenesis factor 7, PTS2R, RCDP1, RD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- enzyme binding
- protein homodimerization
- WD40
- peroxisome targeting signal-2 receptor
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- peroxisome biogenesis disorder 9B
- rhizomelic chondrodysplasia punctata type 1
- hereditary disorder
- rhizomelic chondrodysplasia punctata
- peroxisome biogenesis disorder
- peroxisome biogenesis disorder complementation group 11
- connective tissue disorder
role in cell
- migration
- endochondral ossification by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- fatty acid beta-oxidation
- neuron migration
- protein targeting to peroxisome
- peroxisome organization
- endochondral ossification
- ether lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- peroxisome matrix targeting signal-2 binding
- enzyme binding