Pdp2 Gene Summary [Rat]
Enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdp2 |
| Official Name | pyruvate dehyrogenase phosphatase catalytic subunit 2 [Source:RGD Symbol;Acc:628812] |
| Ensembl ID | ENSRNOG00000012343 |
| Bio databases IDs | |
| Aliases | pyruvate dehyrogenase phosphatase catalytic subunit 2 |
| Synonyms | 4833426J09RIK, Gm1705, KIAA1348, LOC100505926, mKIAA1348, PDPC 2, PPM2B, PPM2C2, pyruvate dehydrogenase phosphatase catalytic subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine phosphatase
- [pyruvate dehydrogenase (lipoamide)]-phosphatase
- phosphatase
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- systemic lupus erythematosus
- chronic lymphocytic leukemia
role in cell
- differentiation
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper cell differentiation
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
- [pyruvate dehydrogenase (lipoamide)] phosphatase activity