Sulf2 Gene Summary [Rat]
Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and glycosaminoglycan binding activity. Involved in positive regulation of endothelin production. Predicted to be located in extracellular region. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sulf2 |
| Official Name | sulfatase 2 [Source:RGD Symbol;Acc:1305078] |
| Ensembl ID | ENSRNOG00000006052 |
| Bio databases IDs | |
| Aliases | sulfatase 2 |
| Synonyms | 2010004N24Rik, HSULF-2, mKIAA1247, MSulf-2, sulfatase 2, sulph2, sulphatase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sulf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- N-acetylglucosamine-6-sulfatase
- Sulfatase
- enzyme
- Sulfatase protein
- arylsulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- premature ejaculation
- epithelial cancer
- epithelial neoplasia
- severe preeclampsia
- growth failure
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- activation in
- sprouting
- function
- proliferation
- binding
- cell death
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Endoplasmic Reticulum
- Golgi stacks
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sulf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- glial cell-derived neurotrophic factor receptor signaling pathway
- glomerular filtration
- innervation
- response to wounding
- positive regulation of canonical Wnt receptor signaling pathway
- chondrocyte development
- embryonic skeletal system development
- bone development
- glomerular basement membrane development
- kidney development
- esophagus smooth muscle contraction
- positive regulation of Wnt receptor signaling pathway
- heparan sulfate proteoglycan metabolic process
- regulation of hepatocyte proliferation
- cartilage development
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- extracellular region
- Golgi stack
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- arylsulfatase activity
- N-acetylglucosamine-6-sulfatase activity