Cyp2e1 Gene Summary [Rat]
Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2e1 |
| Official Name | cytochrome P450, family 2, subfamily e, polypeptide 1 [Source:RGD Symbol;Acc:2475] |
| Ensembl ID | ENSRNOG00000012458 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 2, subfamily e, polypeptide 1 |
| Synonyms | CPE1, CYP2E, CYPIIE1, cytochrome P450 family 2 subfamily E member 1, cytochrome P450, family 2, subfamily e, polypeptide 1, P450 2e1, P450C2E, P450-J |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp2e1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- oxygen binding
- oxidoreductase
- heat shock protein binding
- enzyme binding
- enzyme
- heme binding
- 4-nitrophenol 2-monooxygenase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- CH-OH group:NAD or NADP oxidoreductase
- monooxygenase
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Cyp2e1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- obesity
- diabetes mellitus
- breast cancer
- head and neck cancer
- hepatocellular carcinoma
- epithelial neoplasia
- epithelial cancer
- cancer
role in cell
- apoptosis
- activation in
- cell death
- necrosis
- expression in
- production in
- synthesis in
- oxidative stress response
- transmembrane potential
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- cell surface
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- Golgi membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp2e1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid biosynthetic process
- steroid metabolic process
- response to bacterium
- long-chain fatty acid metabolic process
- epoxygenase P450 pathway
- lipid hydroxylation
- halogenated hydrocarbon metabolic process
- xenobiotic metabolic process
- monoterpenoid metabolic process
- 4-nitrophenol metabolic process
- carbon tetrachloride metabolic process
- benzene metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- arachidonic acid epoxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- monooxygenase activity
- heme binding
- oxidoreductase activity
- iron ion binding
- aromatase activity
- Hsp90 protein binding
- 4-nitrophenol 2-monooxygenase activity
- Hsp70 protein binding
- enzyme binding