Mier3 Gene Summary [Rat]
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer and lung adenocarcinoma. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mier3 |
| Official Name | MIER family member 3 [Source:RGD Symbol;Acc:1311241] |
| Ensembl ID | ENSRNOG00000013121 |
| Bio databases IDs | |
| Aliases | MIER family member 3 |
| Synonyms | 5730509D14, D130064H19Rik, MIER family member 3, RGD1311241 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mier3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- ELM2 domain
- Myb-like DNA-binding domain
- protein binding
- Mesoderm induction early response protein 1/3 C-terminal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mier3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone deacetylase binding
- histone deacetylase activity
- transcription corepressor activity